Search results for " aminoindoles"

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Docking of indolo- and pyrrolo-pyrimidines to DNA. New DNA-interactive polycycles from amino-indoles/pyrroles and BMMA

2004

New indolo- and pyrrolo-pyrimidines of type 1-4 were studied for their ability to form stable complexes with DNA fragments. The calculated free energies of binding were found in the range -8.39 ÷ -16.72 Kcal/mol. The docking studies revealed a common binding mode with the chromophore intercalated between GC base pairs whereas the side chain lies along the minor groove.

Base pairStereochemistryOrganic ChemistryChromophoreSettore CHIM/08 - Chimica Farmaceuticalcsh:QD241-441chemistry.chemical_compoundlcsh:Organic chemistrychemistryDocking (molecular)Docking DNA interaction indolopyrimidine pyrrolopyrimidine aminoindoles aminopyrroles BMMASide chainFree energiesDNAMinor groove
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‘Interrupted’ diazotization of 3-aminoindoles and 3-aminopyrroles

2014

Abstract ‘Interrupted’ diazotization of 3-aminoindoles and 3-aminopyrroles, achieved by quenching with cold water immediately after the addition of nitrite, led, in good yields, to stable compounds whose structures were identified to be the diazonium species with nitrate as the counter ion, which show no saline character.

chemistry.chemical_classificationQuenching (fluorescence)Organic ChemistryInorganic chemistryPhotochemistryBiochemistrySettore CHIM/08 - Chimica Farmaceuticachemistry.chemical_compoundchemistryNitrateDrug DiscoveryAmino pyrroles Aminoindoles Diazoindoles Diazo pyrrolesNitriteCounterion
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